Mr Varshan Gounden graduated cum laude with a Master of Science in Biochemistry, leaving a strong mark in the field of cancer research.

Supervised by Professor Moganavelli Singh, Gounden’s dissertation titled: ‘Gold Nanoparticle-Chitosan Hydrogel Mediated Wound Healing and Delivery of 5-Fluorouracil to Cancer Cells in vitro’, explored a novel therapeutic approach with the potential to transform both oncology treatment and wound care.

Gounden’s journey into biochemistry was inspired by a lifelong passion for science and a desire to make a difference in the realm of patient care. Having already completed his honours degree under Singh’s mentorship, the decision to continue at UKZN was a natural one. “She provided a strong platform for young scientists like myself to learn, grow and refine our research skills,” said Gounden.

His master’s research addressed a dual challenge in medical science: effective chemotherapy drug delivery and the need for enhanced wound healing. The project aimed to create a hydrogel system composed of gold nanoparticles and chitosan – a natural polymer – that could perform two vital functions. Firstly, in the context of cancer treatment, the hydrogel enabled a pH-responsive release of the chemotherapy drug 5-fluorouracil, targeting the acidic environment of tumors. This selective delivery minimised harmful effects on healthy tissue and reduced systemic side effects. Secondly, for wound healing, the hydrogel acted as a biocompatible scaffold, encouraging cell growth and tissue regeneration.

“This dual-functional system offers a promising strategy for precision oncology and wound healing,” Gounden noted. “It has the potential to enhance significantly both therapeutic effectiveness and patient quality of care.”

Looking to the future, Gounden hopes to transition from research into the pharmaceutical industry, where he aims to contribute to evidence-based medical strategies. “The ultimate goal is to join the medical team where I can bridge the gap between research and clinical application,” he said.

Gounden credited his sister, Ms Sayuri Gounden, as his biggest inspiration and the foundation for his academic success. “Through her unwavering hard work and determination, she has shown me that with perseverance and dedication, anything is possible.” He also paid tribute to his parents, whose “guidance and belief” were instrumental to his success.

Outside the lab, Gounden makes time for recreational gaming, spending time with loved ones and running, all of which help maintain his physical and mental well-being.

In reflecting on his academic journey, Gounden said: “I would like to sincerely thank everyone who has supported me throughout this journey, and I hope that this achievement serves as a stepping stone toward even greater accomplishments in the future.”

Words: Sally Frost

Photograph: Sethu Dlamini